Tuesday, February 14, 2017

Effective Of Collagen Peptide On Osteoarthritis

Osteoarthritis (OA) is the most common type of arthritis and the major cause of chronic musculo-skeletal pain and mobility disability in the elderly population worldwide. The characteristic features of this chronic, progressive and degenerative disorder of the entire joint include variable inflammation and changes in the structure of bone bordering the joint and in the protective cushion called articular cartilage. Clinical manifestations include joint pain, tenderness, limitation of movement, effusion and varying degrees of inflammation, and finally induce disability in many patients.

The principal components of articular cartilage are the insoluble fibrous protein collagen and the soluble proteoglycans. A complex organisation of collagen, proteoglycans and the fluid environment endows the tissue with the capacity for reversible deformability, a property essential for its physiological function. The integrity of cartilage tissue is dependent on the complex network of type II col-lagen, proteoglycans and accessory proteins such as fibronectin. These molecules are synthesised and integrated into the residual extracellular matrix (ECM) by chondrocytes. The loss of ECM in car-tilage is associated with an increased cleavage of type II collagen by collagenase and an aggrecan cleavage along with the degra-dation of small proteoglycans.1 Alterations in the collagen fibril network have been observed including extensive changes in the collagen fibril orientations, especially in the superficial zone and reduction in the collagen content.2,3 Although the loss of aggrecan in articular cartilage is essential for the progression of OA, the final cartilage damage is inflicted by the loss of the collagen network.4 Current pharmacological treatments widely use non-steroidal anti-inflammatory drugs (NSAIDs) as therapeutic agents for OA despite their adverse effects on long-term usage. An alterna-tive treatment with nutritional supplements with higher levels of safety and effectiveness attracts much attention. By nature nutri-tional supplements are better positioned to provide long-term health benefits.

Collagen-based peptides represent functional peptides that exhibit various physiological activities. Bone mineral density has been shown to be increased by the oral ingestion of gelatin.5 Folk medicines always mention the positive influence of collage-nous preparations as being beneficial to joint health, skin, hair and nails.6 –8

Several studies show that enzymatically hydrolysed collagen (known as gelatin hydrolysate or collagen hydrolysate or collagen peptide) is absorbed and distributed to joint tissues and has anal-gesic and anti-inflammatory properties. The protein has a typical and unique amino acid composition in that it is very rich in glycine, proline and hydroxyproline. Research in mice has demonstrated that after oral administration of radiolabelled gelatin hydrolysate the radioactivity was specifically found in cartilage.9 Animal exper-iments have suggested that oral ingestion of collagen peptide might have beneficial effects on joint health such as OA. A recent study in animal models demonstrated that collagen peptide reduced the morphological changes associated with osteoarthritic cartilage destruction in knee joints.10

Being a protein with rich source of amino acids specifically found in collagen, it is worthwhile performing a clinical evaluation of the substance to understand the health benefits in the manage-ment of OA. Hence the present study was planned with an aim to assess the effectiveness of pork skin collagen peptide (PCP) man-ufactured from pork skin and bovine bone collagen peptide (BCP) in subjects with clinically diagnosed knee OA.


Both pork skin collagen peptide (PCP) and bovine bone collagen peptide (BCP) are effective supplements for the improvement in overall physical problems associated with OA and thereby help to improve the quality of life. It is hypothesised that the supplementation of collagen peptide regulates chondrocyte differentiation and stimulates synthesis of proteoglycans, resulting in the initiation of repair processes in cartilage tissue.


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